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A Commentary On Biblical Babylon
The great city and empire of Babylon on the Euphrates river in the land of Shinar, was like a huge fortress, and became a mighty religious and economic center of commerce in circa 600 to 500 BC. It opposed the Creator-God and proudly exalted self over all mankind and all religions as the Holy Bible shows, and was hated by God for its evil, excesses and cruelty.  – Compiled here by R. DeWitt: 09/2012 from the biblical account in the Concise Bible Dictionary. 

"The moral features of Babylon were idolatrous corruption and worldliness, which will be seen in full manifestations in Babylon the Great in Revelation 17:5. It is [viewed as] the place where the people of God get into captivity through dalliance with the world.

"In the N.T., Babylon is mentioned in 1 Peter 5:13 [where those of the elect are found]. There is evidence in Josephus [his writings] that there were many Jews in the district forty years after Christ. On the occasion of the gathering at Jerusalem in Acts 2:9-11 mention is made of the Parthians, Medes and Elamites; and when Peter commences his epistle, supposing he was in the district of Babylon, he naturally puts Pontus first and then passes on to Galatia, Cappadocia, Asia, and Bithynia. There can be no reason therefore to doubt that the ancient district of Babylon is alluded to by Peter, where, through God's grace, there were some of the 'elect'.

"Babylon the Great is also called 'mystery', the 'mother of the harlots and of the abominations of the earth' (Rev. 17:5). Some great religious system is alluded to, with whom the kings of the earth had illicit intercourse, and by whom the merchants of the earth had been made rich. It had also been guilty of shedding the blood of the saints and the blood of the martyrs of Jesus. It is compared to a woman arrayed in purple and scarlet, and decked with gold and precious stones and pearls, having a cup in her hand, full of abominations and filthiness of her fornication. Could there possibly be drawn a more vivid and life-like portrait of the worldly and idolatrous system of the apostate Church, whose center is at Rome, than is here drawn by the pen of the Holy Spirit? To make it doubly sure as to who is represented by the description it is added in verse 9: 'the seven-hilled city' being a well-known appellation of Rome.

"It is further revealed that the ten horns (the ten kingdoms of the future Roman empire --when revived) will make war with the woman, make her desolate and naked, will eat her flesh and burn her with fire. Heaven and the Apostles and Prophets are called on to rejoice over the fall of that seductive and soul-destroying system: see Rev. 14:8; 16:19; 17:1-18; 18:1-24; 19:1-3.

"It should be noted that though Papal Rome is one of the worst of the anti-christs, and the one that has had sway for the longest period; yet she is not what is called in Scripture 'the antichrist' or 'man of sin" [which refers to the second beast embodied by Satan during the Tribulation time]. 
  - Concise Bible Dictionary: see Bible Truth Publishers, Addison, IL; - RLD: RP08